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According to Kong Yulong, deputy chief physician of the Department of Dermatology at Nanjing Jiangbei Hospital, adenosylcobalamin is similar to vitamin B12 in that it does have certain positive effects on nerve nourishment, regulating nerve secretion, and improving circulation, but there is currently no further research on its use in treating gray hair

It works by mimicking a hormone called GLP-1, which regulates hunger and food intake

[10] Enzyme-inducing anticonvulsants such as phenytoin, carbamazepine, and phenobarbital, as well as rifampicin, accelerate hepatic catabolism of vitamin D, shortening its half-life and potentially necessitating more frequent or higher intramuscular doses to sustain target 25-hydroxyvitamin D levels