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L-carnitine supplementation improves serum lipid parametersincluding total cholesterol (TC), triglycerides (TG), and low-density lipoprotein (LDL) in NASH patients ( ) intervention for 6 months significantly decreased controlled attenuation parameter (CAP) values in NAFLD patients, indicating reduced hepatic steatosis ( Molecular regulation of fatty acid -oxidation extends beyond core enzymatic machinery (CPT1, CPT2) to include sophisticated transcriptional and post-translational control mechanisms involving AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor (PPAR), and peroxisome proliferator-activated receptor coactivator-1 (PGC1) ( Ppar gene expression in NASH mice after L-carnitine treatment, while Ishikawa et al

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coli After having selected the enzymes for the L-carnitine biosynthetic pathway, expression of the four genes was optimized by combining the individual genes in a single plasmid as a synthetic operon