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Individuals taking medication should discuss potential interactions with their healthcare professional

Quantification of SUMOylation assays was performed through densitometry analysis using ImageLab (BioRad) to quantify the volume of the 65kDa anti-TDP-43 bands from the immunoprecipitation standardized to the loading control of the input

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Since A does not accumulate in any of these apoE isoform transgenic mouse models, these data strongly suggest an A-independent role of apoE4 in causing neuronal and behavioral deficits in vivo