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Origin, Formation, and Regulation of 4-HNE In 1980, Esterbauer and colleagues identified 4-HNE as one of the major cytotoxic substances produced by lipid peroxidation (3)

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doi: 10.1074/jbc.273.26.16058 113

Children, Wei, J., Yao, J., Yang, C., Mao, Y., Zhu, D., Xie, Y., Liu, P., Yan, M., Ren, L., Lin, Y., Zheng, Q., & Li, X