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It is more dangerous with higher doses or prolonged usage

10.1093/brain/awm304 Brain 7 BosM

Unlike ADH, however, the MEOS follows first-order kinetics

35,507 Notably, in addition to the constitutive 26S proteasome, three other proteasome isoforms, including the spermatoproteasome, thymoproteasome, and immunoproteasome, exhibit tissue-specific expression