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For example, after coated with a silica layer, the zinc dioxide (ZnO) NPs exhibited less cytotoxicity in human dermal fibroblast cells with less enzyme leakage, ROS production, and oxidative stress than their bare NPs, as a result of the surface modification restricting formation of free radicals and the release rate of zinc ions, as well as reducing the surface interactions of ZnO NPs with cells (Ramasamy et al., 2014)

Limitations of Mechanism Studies While these mechanisms are fascinating from a research perspective, they represent the beginning of understanding, not established facts about human physiology

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