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When free radicals damage our cells, the ability of the mitochondria to convert glucose into fuel is hindered leading to a decrease in energy production and metabolism

Furthermore, through mechanisms such as acidification of the microenvironment, this metabolic shift fosters an immunosuppressive environment favorable for tumor survival, thereby significantly increasing the invasive and metastatic potential of tumor cells [19]

Safety Toxicity The Food and Nutrition Board did not set a tolerable upper intake level (UL) for thiamin because there are no well-established toxic effects from consumption of excess thiamin in food or through long-term, oral supplementation (up to 200 mg/day)