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Hydroquinone works by reducing the production and increasing the degradation of melanin pigments in the skin

GST M2-2 is a prostaglandin E synthase in the brain cortex [8] and rat GST A1-1 and GST A3-3 catalyze the reduction of PGH 2 to PGF 2

Relatedly, it is believed that the loss of dopamine neurons in the basal ganglia is what is primarily responsible for the movement problems often seen in Parkinsons patients, such as tremors and rigidity [68]

Loss-of-function TNSALP mutations lead to ineffective PLP dephosphorylation to pyridoxal, reduced pyridoxal transfer into the brain, and accumulation of PLP in blood ( Several proteins are involved in the formation of GPI anchors that tether extracellular tissue non-specific alkaline phosphatase to the cell membrane