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Iannone LF

Adv Protein Chem Struct Biol (2019) 116:37596

Virili C, Bassotti G, Santaguida MG, Iuorio R, Del Duca SC, Mercuri V, Picarelli A, Gargiulo P, Gargano L, Centanni M

Key Points Tendinopathy is a complex multi-faceted tendon pathology commonly associated with overuse Most current treatments for tendinopathy are neither effective nor evidence-based Many recent studies have highlighted inflammatory cell infiltrates in both animal and human tendon disease The potential roles of inflammatory mediators acting on the resident tenocytes are the source of some controversy and require in-depth investigation using in vitro and in vivo models Understanding the key inflammatory pathways affecting extracellular matrix regulation and homeostasis are critical in designing future targeted therapies for tendinopathy Abstract Tendinopathy is a multifactorial spectrum of tendon disorders that affects different anatomical sites and is characterized by activity-related tendon pain