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Between 2 and 12% of patients receiving high-dose MTX therapy may get acute kidney injury, mostly as a result of crystal nephropathy caused by MTX and its metabolite, 7-OH-MTX

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The velocity constant for the transport of carnitine from muscle to plasma is about 0.0005 h 1 , which means that the half-time for carnitine transportation from muscle to plasma is about 56 days