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The discovery that NNMT expression is dramatically elevated in adipose tissue of obese humans and animal models, and that NNMT inhibition or knockdown prevents diet-induced obesity and improves metabolic health, has catalyzed intense research interest in NNMT as a therapeutic target for obesity, metabolic syndrome, and related conditions

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(1994) Three years of growth hormone treatment in growth hormone-deficient adults: near normalization of body composition and physical performance

Despite their reduced ability to capture the therapeutic antibodies, the high number of these cells suggests that they could act as carriers of anti-CD38 antibodies in biological fluids