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Moreover, the variants exhibited Flex ddG values ranging from 0.8 kcal/mol to 2.4 kcal/mol, implying a limited effect on binding affinity, which might be attributed to variants being distant from protein binding interfaces (Fig

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Usually "suspicious" cytology and follicular proliferation leads to resection, since about 25% of nodules with this cytological picture are carcinomas at final pathology Table 18-3Factors to be Considered in Management of Cold Nodules THYROXINE TREATMENT If a benign result is obtained on cytologic examination, the patient is followed intermittently and may, or may not, be given mildly "suppressive" doses of thyroxine

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