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Traditional risk factors for CVD include hypertension, hyperlipidemia, diabetes, obesity, smoking, etc

Moreover, substances such as statins, angiotensin-converting enzyme inhibitors, or AT1-receptor blockers, which possess indirect antioxidant properties mediated by the stimulation of NO production and by the simultaneous inhibition of superoxide production, have been shown to improve vascular function in pre-clinical and clinical studies and to reduce the incidence of cardiovascular events in patients with cardiovascular disease (Mnzel et al., 2010)

We 46 and other groups 83,84 have already proposed that glutaminase-targeted therapies can be combined with other targeted therapies to seek improved benefits

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