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Description

Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma

Several O-GlcNAcylation targets related to PDAC metabolism and progression, such as notch receptor 1 promoting cancer development [66], SRY-box transcription factor 2 regulating self-renewal [67], sirtuin 7 (SIRT7) triggering cancer progression by blocking the SIRT7-proteasome activator subunit 3 (PAME3) interaction [68], and nuclear factor kappa B modulating cancer-associated inflammation [69], have been reported