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The conserved residue Tyr9 is positioned within hydrogen-bonding distance of the thiolate group of GSH, and this residue has been shown to be important for the catalytic activity of the enzyme 19

Within the complex disease context, fundamental questions remain regarding the specificity, detectability, and spatiotemporal dynamics of ferroptosis, as well as its interactions with classical pathological pathways such as A, tau, -synuclein, and mutant huntingtin protein

In cells dependent on glucose for survival, glucose withdrawalinduced ROS generation and tyrosine kinase signaling synergize to amplify ROS levels, ultimately resulting in ROSmediated cell death

A., Pakmehr M., Shahbazian H., Ahmadi I., et al