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95,96 Excessive endoplasmic reticulum stress leads to an increase in trypsin activity, which in turn stimulates PAR2 and PAR4 receptors, increases intestinal permeability, destroys the function of the intestinal barrier, and promotes the development of inflammatory processes

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2,4-Dichlorophenoxyacetic acid (2,4-D) a primary constituent in Agent Orange was identified as being statistically significant risk for PD (OR 2.59, 95% CI 1.036.48, p = 0.04)