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A., Drosten, C

Furthermore, an interpretable XGBoost model achieved strong performance in predicting ICU mortality among AP patients, with an external validation AUROC of 0.89, surpassing established metrics such as the APACHE IV score and the Sequential Organ Failure Assessment score

2012;7(1):e29325

Physiological stimuli such as shear stress or G protein-coupled receptor (GPCR) agonists like bradykinin promote Ca 2+ entry, leading to dissociation of the Cav-1-eNOS complex and allowing eNOS to be activated via phosphorylation by kinases such as Akt (Feron et al., 1998)