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This helped to reveal the way peptides in the body are produced (Sims, Carr, Oram)

He didnt call it Pernicious Anaemia, but published a paper about his findings and referring to various continental doctors findings in this area so he is often credited with being the first to discover the condition

277 Taken together, these findings demonstrate that SIRT1 exerts protective effects against vascular endothelial senescence by transcriptionally inhibiting PAI-1 expression through H4K16 deacetylation-mediated epigenetic regulation

Using this probe, the zinc concentration in the Golgi of HeLa cells was estimated at 25 1 nM, supporting a role for labile zinc in secretory pathway regulation 193