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Another culprit that has been with me for many years is GERD (gastroesophageal reflux disease)

[DOI] [Google Scholar] 102.Stambolija V., Stambolija T.P., Holjevac J.K., Murselovic T., Radonic J., Duzel V., Duplancic B., Uzun S., Zivanovic-Posilovic G., Kolenc D., et al

However, increasing evidence now indicates that cancer cells transport a significant portion of glucose-derived pyruvate into mitochondria where it serves as an anaplerotic substrate to replenish tricarboxylic acid (TCA) cycle intermediates used for biosynthesis

The balance between these two polarized macrophages is important because previous studies demonstrated that TAMs are predominantly M2-like macrophages and they are associated with cancer progression 16,17,18