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Their findings revealed a significant reduction in glucose production and expression of both G6pc and Pck1 in hepatocytes with NNMT overexpression and concurrent Sirt1 inhibition, compared to hepatocytes with NNMT overexpression alone

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In terms of chemical composition, triterpenoid saponins, flavonoids, various alkaloids, kernel oil rich in unsaturated fatty acids, polysaccharides, and trace elements collectively constitute the complex and synergistic material basis of ZSS, exhibiting multi-component, multi-target, and multi-pathway advantages in antidepressant and neuropsychiatric intervention

Several scientific evidences suggest that different extraction methods can yield varied phytochemical constituents of the evaluated plant extract and plays critical role in determining its biological potential