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NRF2 is also required to couple mitochondrial biogenesis with mitophagy by inducing BNIP3 expression, which is essential for facilitating cancer progression (Riis et al., 2020)

The extracellular matrix: an active or passive player in fibrosis

It was indicated that ferroptosis inducers promoted copper ionophore-induced cell death in primary liver cancer cells, suggesting that the agents can trigger not only ferroptosis but also cuproptosis