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Use this design when: You want to compare the effects of different treatments within the same individuals The treatments have temporary effects with a known washout period You want to increase statistical power while using a smaller sample size You want to control for individual differences in response to treatment Advantages Prevents bias In randomized control trials, participants must be randomly assigned to either the intervention group or the control group, such that each individual has an equal chance of being placed in either group

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Dis Model Mech 5:155164 Rouault TA (2015a) Mammalian iron-sulphur proteins: novel insights into biogenesis and function