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[DOI] [PMC free article] [PubMed] [Google Scholar] 141.Kadry H., Noorani B., Cucullo L

The 2012 fungal meningitis outbreak caused by contaminated compounded medications from a Massachusetts pharmacy remains a landmark case showing catastrophic consequences of poor sterile compounding practices

Because early symptoms are insidious, inflammation within the synovium and joint space often intensifies by the intermediate stage, and lesions extend into the cartilage, with extracellular matrix (ECM) degeneration, fibrosis within calcified cartilage, and chondrocyte hypertrophy (Mahmoudian et al., 2021)