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Ding X, Saxena NK, Lin S, Gupta NA, Anania FA

Human & Experimental Toxicology

Animal studies have shown that the BCL-2 family inhibitors ABT263 (Navitoclax) and ABT737 effectively eliminate SA--Gal-positive senescent cells, significantly enhancing the function of multiple systems and tissues, such as the haematopoietic and pulmonary systems, as well as skeletal muscle tissue [192, 212]