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AZD3965 has been reported to enhance intracellular acidosis through increased intracellular lactate and decreased extracellular lactate 53

Similarly, buspirone was shown to ameliorate cyclophosphamide-induced damage in an experimental model of premature ovarian insufficiency, where its protective actions were associated with the regulation of oxidative stress-related pathways such as AMPK/Nrf2/HO-1 and -Klotho/NLRP3 signaling and a concomitant decrease in caspase-3-mediated apoptosis (Khallaf et al