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Materials and methods Cell culture The human pancreatic cancer cell lines (CFPAC-1, SW1990, PANC-1, and BxPC-3) and murine pancreatic cancer cell line (Pan02) were procured from the Cell Bank of the Chinese Academy of Sciences Type Culture Collection (Shanghai, China)

Similar content being viewed by others Introduction The transcriptional coregulator and a core component of the Polycomb Repressive Deubiquitinase (PR-DUB) complex, ASXL1 (additional sex combs like 1), is frequently mutated and truncated in human malignances, particularly in acute and chronic myeloid leukemias (AML and CML, respectively) and myelodysplastic syndromes (MDS) 1,2,3,4,5,6,7 (Fig

Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection

Finally, BOLD fMRI data were collected with an echo-planar imaging (EPI) sequence: TE = 30 ms, TR = 2500 ms, 90 degree flip angle, interleaved acquisition of 36 slices of 128 128 voxels (1.72 1.72 mm), 3.0 mm slice thickness with 0.5 mm gap (3.5 mm slice spacing)