fsp1 is a glutathione-independent ferroptosis suppressor.

fsp1 is a glutathione-independent ferroptosis suppressor. The sketchy role of FSP1, GPX4, and system Xc- in ferroptosis. Under Ferroptosis inhibitors: mechanisms of action

Name: fsp1 is a glutathione-independent ferroptosis suppressor. The sketchy role of FSP1, GPX4, and system Xc- in ferroptosis. Under Ferroptosis inhibitors: mechanisms of action
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Ferroptosis inhibitors: mechanisms of action and therapeutic potential Cellular and Molecular Life Sciences Springer Nature Link FSP1: a key regulator of ferroptosis: Trends in Molecular Medicine Structure and Function of FSP1 Encyclopedia MDPI The suppression of FSP1 expression via NRF2 promotes ferroptosis induced by reactive oxygen species in vascular smooth muscle cells ScienceDirect

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Acknowledgments The authors would like to thank Jassi Gutierres and Gustavo Thom for the figure design

Compound 102 exhibited GPX4 activating effects in a concentration-dependent manner ( Figure 3 and Supplementary Figure S3 ), with both increased ratio of 5-HETE and LTB 4 and increased concentrations of 12-HETE and 15-HETE

Synthesis and anticancer activity of some novel 2-phenazinamine derivatives

Yet, under regulation of the ISR pathway an ATF4-mediated upregulation of NRF2 via CHAC1 activity was shown as well ( 2.3.1 The dual role of CHAC1 in cancer CHAC1s function in cancer is complex and highly context-dependent