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Obesity has been observed to shift the asthmatic immune response away from the classic T2 high eosinophilic inflammation towards a T2 low phenotype, promoting a more Th1 and Th17-skewed profile, contributing to cell-mediated immunity and sustained inflammation [39]

Chem Biol Interact 298:112120

Animal studies suggest that cochlear synaptopathydefined as the loss of synapses between IHCs and auditory nerve fibersmay contribute specifically to central auditory hyperactivity and tinnitus following noise exposure 41