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GR is another critical enzyme involved in antioxidant defense and responsible for reducing GSSG back to its reduced form GSH, which is pivotal for the cellular antioxidant protection 53

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Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that, upon activation, translocates to the nucleus and binds antioxidant response elements (AREs) in DNA to drive expression of antioxidant genes