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Description

MicroRNA-223 suppresses IL-1 and TNF- production in gouty inflammation by targeting the NLRP3 inflammasome

10.1038/s41586-019-1847-2 148 TauffenbergerA.FiumelliH.AlmustafaS.MagistrettiP

METAOD004: A Phase IIa (double-blind, placebo-controlled, dose escalation) safety study with multiple daily doses (9, 27 or 54 mg AOD9604) administered orally (capsules) for seven days in 36 healthy clinically obese males presenting with a BMI 30 kg/m 2