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Razzaque, Lake Erie College of Osteopathic Medicine, United States Reviewed by Naseh Pahlavani, Torbat Heydarieh University of Medical Sciences, Iran

TMAO can aggravate acute electrical remodeling in AF models and enhance atrial electrophysiological instability in normal canines by enhancing autonomic remodeling and boosting the p65 NF-B signaling pathway [84]

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In a randomized, placebo-controlled study of 495 patients with intermittent claudication, 2 g/day of propionyl-L-carnitine for 12 months significantly increased maximal walking distance and the distance walked prior to the onset of claudication in patients whose initial maximal walking distance was less than 250 meters (m), but no effect was seen in patients who had an initial maximal walking distance greater than 250 m (65)