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IFN, the only known type II IFN (IFNII), mainly signals via phosphorylated STAT1 homodimers that recognise gammaactivated DNA sequences (GAS) and express a distinct set of ISGs

It may also help to improve low sperm counts by decreasing levels of oxidative damage to the sperm, which can lead to infertility

In contrast, activated microglia persist at a low level in chronically demyelinated lesions in mice treated with cuprizone up to 12 weeks (Mason et al., 2004