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When norepinephrine is released into the synapse between neurons, the amount of norepinephrine available there is controlled by the norepinephrine transporter, NET.[ref] In POTS, research points to an excess of norepinephrine signaling, and this could be due to decreased NET activity, essentially allowing too much norepinephrine to remain in the synapse

PubMed, Fountain, John H., and Sarah L