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ShM: Methodology, Supervision, Writing review & editing

This finding is consistent with the speculation that p53 is widely regarded as undruggable. Surprisingly, several novel therapeutic approaches targeting p53, including MDM2/4 antagonists, compounds that target specific p53 mutants or restore the wild-type function of the mutated p53 protein, p53-based genetic therapies and p53-based tumor immunotherapy, have been developed in recent years

"Modeling kinetic rate variation in third generation DNA sequencing data to detect putative modifications to DNA bases"

The cell arrangement was slightly disordered in groups C and D, but the pathological changes were more obvious than those in groups A1, 2 and 3