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This single small molecule affects more than 31% of human genes, upregulating repair pathways while simultaneously suppressing inflammatory and potentially harmful gene expressions

How vitamin B12 is absorbed and stored in the body B12 must be absorbed through food, is found exclusively in animal foods and is then transported into the bloodstream via a special transport route with the help of the so-called intrinsic factor

While the mitochondrial thiamine partners described above clearly make vitamin B1 extremely important for energy homeostasis, its role as a cofactor of cytosolic transketolase is also very interesting since this enzyme catalyzes the first and last step of the pentose phosphate pathway allowing, on the one hand, NADPH production which is required to cellular antioxidant defenses (as a cofactor of glutathione reductase in particular) (Figure 2), and on the other hand, ribose generation for nucleotide synthesis

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