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Animal experiment also documented correlations of serum UA levels with lower striatal dopamine levels, tyrosine hydroxylase-positive neuronal death in the SN pars compacta, and the degree of oxidative stress in the midbrain

Rokkas et al

1 Introduction Regulated cell death is a fundamental biological process essential for tissue homeostasis and organismal integrity, and its dysregulation is increasingly recognized as a central driver of neurological disorders and brain malignancies ( Mounting evidence implicates ferroptosis in a broad spectrum of central nervous system (CNS) disorders, including acute brain injury, neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinsons disease (PD), demyelinating disorders such as multiple sclerosis (MS), and primary brain tumors such as glioma ( Despite these advances, the interplay between ferroptosis and immune regulation in CNS disorders remains insufficiently understood

10.12944/cwe.5.2.12 24 NowickaB