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PMID: 39747971 Brain Res Bull Nerol ameliorates cognitive dysfunction in vascular dementia rats by inhibiting mitochondrial oxidative stress and reducing hippocampal senescence

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then increase to 20 mcg once daily on day 15 Maximum: 20 mcg subcutaneous injection once daily Liraglutide (Victoza) Long-acting Dosage Initial: 0.6 mg subcutaneous injection once daily for one week, then increase to 1.2 mg once daily Maximum: 1.8 mg subcutaneous injection once daily Dulaglutide (Trulicity) Long-acting Dosage Initial: 0.75 mg subcutaneous injection once weekly, then may increase to 1.5 mg once weekly after four to eight weeks if needed to achieve blood sugar goals Maximum: 4.5 mg subcutaneous injection once weekly

They have discovered that polyphenols may exhibit the ability to scavenge free radicals through (1) direct reaction with reactive oxygen species (ROS), (2) enhanced dismutation of free radicals to compounds with much lower reactivity, (3) inhibition of catalase enzyme activity, (4) increased activity of antioxidant enzymes such as SOD, (5) chelation with pro-oxidative metals like iron and copper, and (6) increasing the effectiveness of other small antioxidants like tocopherols and ascorbic acid [208, 209]