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the major mechanisms by which the drug is cleaved from the antibody include hydrolysis in the acidic pH of the lysosomes (hydrazones, acetals, and cis-aconitate-like amides), peptide cleavage by lysosomal enzymes (the cathepsins and other lysosomal enzymes), and reduction of disulfides

Mechanistically, under the action of ultrasound, this system not only exhibits traditional CAT-like and POD-like activities to modulate ROS levels but also facilitates macrophage polarization from the pro-inflammatory M1 phenotype to the regenerative M2 phenotype [Figure 9C]

Our findings suggest that cell proliferation may not be the primary cause of DNA damage signals in cells from aged killifish (Fig

Oncogene 35 , 26872697 (2016)