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Following UVA exposure, TT-dimers were detectable in the skin and urine of all participants, indicating a role for UVA radiation in CPD formation

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While the transappendageal pathway, which utilizes appendages such as hair follicles, sweat ducts, and sebaceous glands, constitutes only about 0.1% of the skin surface area (though this percentage may be higher in specific regions such as the forehead) [22], its contribution to percutaneous transport is generally considered secondary

Pharmacokinetics of IL-18 Binding Protein in Healthy Volunteers and Subjects With Rheumatoid Arthritis or Plaque Psoriasis