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Clinically, a meta-analysis of 14 randomized controlled trials ( n = 1,154) found that probioticTCM combinations were superior to 5-ASA monotherapy, probiotic monotherapy, or TCM monotherapy in inducing clinical remission, reducing relapse rates, and lowering adverse events ( 6.3 Targeted delivery systems To address the limitations of oral administration, novel delivery platforms have been developed around three objectives: preserving probiotic viability and promoting colonization, achieving precise targeting of inflamed sites, and enabling synergistic, multipathway therapy

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