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Plasma levels of TMAO are reportedly positively associated with cardiovascular risk and mortality in a dose-dependent manner ( Table 1 The negative effects of TMAO on atherosclerosis demonstrated via clinical and non-clinical experiments

The role and effectiveness of the first line defense antioxidants which basically include superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) is therefore important and indispensable in the entire defense strategy of antioxidants, especially in reference to super oxide anion radical (O2) which is perpetually generated in normal body metabolism through several processes

doi: 10.1186/s12951-024-02842-5 180 ChenXComishPBTangDKangR

doi: 10.3389/fphar.2023.1275000 237 ChenJHuangZChenYTianHChaiPShenYet al