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Studies in animals show that systemic administration produces healing effects at distant sites

The acquired resistance of tumor cells to TKIs is partially reversed by inhibiting IGFBP-1 and the combination of antiangiogenic TKIs and IGFBP-1 inhibitors may be a promising therapeutic strategy for HCC (135)

Daraufhin produziert diese in den meisten Fllen unzhlige neue Viruspartikel, aus denen weitere Viren zusammengesetzt werden man spricht von Virusreplikation