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2020;5(9):e132747

Early menopause from cancer treatment is different to the gradual transition that usually happens with a natural menopause

doi: 10.1016/j.gene.2012.08.038 594 SonYKimSChungHTPaeHO

The mechanism of hyperpigmentation in seborrhoeic keratosis involves the high expression of endothelin-converting enzyme-1alpha and TNF-alpha, which stimulate secretion of endothelin 1