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However, most previous silicosis studies overlooked significant changes in the biomechanical micro-environment in fibrotic lungs and the impact on cell function

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Metabolic flux analysis using C-labeled cystine revealed that a significant portion of intracellular cystine is channeled into the biosynthesis of coenzyme A (CoA)

Importantly, this junction also represents the entry point into the pentose phosphate pathway (PPP), which shunts glucose away from energy production and instead generates NADPH, an essential cofactor required for glutathione synthesis and redox homeostasis