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DOI: 10.1146/annurev.med.52.1.108 GH Deficiency and Replacement Research Extensive pre-clinical and clinical research using recombinant hGH has characterised the effects of GH deficiency across the lifespan from childhood growth failure to adult-onset GH deficiency with associated body composition, metabolic, and quality-of-life effects establishing the pharmacological profile of HGH 191AA replacement in deficiency models that forms the pre-clinical basis for current GH replacement research

Xie Y, Zheng J, Li S, Li H, Zhou Y, Zheng W, et al

An emerging mechanism, cartilage regeneration In the last decade, studies have appeared suggesting that AOD-9604 may also have an effect on cartilage regeneration (chondrocytes)

Another possible scenario exists, that being that the shot is so close to these nerve fibrils that the volume of the shot causing a local stretching to the nerve fibrils