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Iron overload alters the number and viability of T-lymphocyte subpopulations and the distribution of lymphocytes in different compartments of the immune system ( C-myc and Mdn2 gene expression ( In relation to the treatment of RA, it has been found that the iron ion chelator desferrioxamine (DFO) has been used to prevent synovial damage and improve RA anemia ( 2.2 Lipid peroxidation in RA Lipid peroxidation is central to ferroptosis

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the lack of glutathione (reduced) may manifest as a systemic deficiency or locally in specific cells undergoing oxidation stress