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Oxidative stress can occur as a result of increased metabolic rate, increased oxygen tension, compromise of normal cellular antioxidants and many others endogenous and exogenous factors (Figure 1)

Miguel Navarro-Alarcn, Carmen Cabrera-Vique - Selenium in food and the human body: a review - Sci Total Environ - 2008 Aug 1 - 400(1-3) : 115-41

In addition because their functional domains are encoded at the amino-acid level, they do not require complex post-synthetic surface engineering, rely only on standard antibody-generation platforms for production, and allow reliable batch-to-batch reproducibility

10.1016/j.clinbiochem.2007.01.012 Clin Biochem