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In lab experiments, they found that both drugs did their job, but KBP-336 was more powerful and leaned more towards activating one of the sensors over the other

Ghiani L, Chiocca S

Consistent with these findings, p53 depletion increased proliferation and CFU-F of MSCs by increasing expression of TWIST2, improved osteogenesis at the expense of adipogenesis by suppressing PPARG, and diminishing mitochondrial ROS production, suggesting p53 is a negative regulator of self-renewal and osteogenesis of MSCs [52]