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Cold air and numbing gel are used to minimize discomfort

Funding This research was supported by the Natural Science Foundation of China (32202641, 32460819, 31960672), the Natural Science Foundation of Ningxia (2025AAC030558, 2025AAC040003), the Central Guidance on Local Science and Technology Development Fund (2024FRD05052) and the Key R & D projects in Ningxia Hui Autonomous Region (2024BBF01007 & 2023BCF01006)

Pomytkin I, Costa-Nunes JP, Kasatkin V et al (2018) Insulin receptor in the brain: mechanisms of activation and the role in the CNS pathology and treatment