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10.1016/j.cmet.2011.03.010 50

Even though most of the studies published over the past years focused on GSTs catalyzing the addition of glutathione, other catalytic activities have been described

After that, Nrf2 enters the nucleus, attaches itself to antioxidant response elements (AREs) found in the downstream target genes 5-flanking promoter/enhancer region, and starts the transcription of those genes

Concerning the metal-chelating ability, both DHLA and ALA, due to the presence of nearby sulfur atoms and a carboxyl group, are capable of chelating redox-active metals